Dr. Campbell’s Principle Research Interests

Dr. Campbell’s principle research interests include: The relationship of diet, nutrition and chronic degenerative disease etiology; nutritional effects on carcinogen and foreign compound metabolism; aflatoxin/liver cancer relationships; risk assessment and chemical toxicity.

In more recent years, his principle interest is in re-defining the concept of nutrition and finding ways to present this information to the public.

Although Dr. Campbell has written over 350 professional research publications, the two most influential for the public are his best-selling books, The China Study (2005) and Whole (2013).

The China Study, which has been translated into about 50 languages and sold well over two million copies, has influenced several well-known people including celebrities like President Bill Clinton, Hall of Fame golfer Gary Player, movie producer James Cameron (Titanic, Avatar). A 2nd Edition of The China Study was released in late 2016 and a collectors’ edition in late 2018. The information in this book summarizes for the public the extensive findings of Dr. Campbell’s research career. Many commentators have stated that, more than any other book in this genre, The China Study, has advanced the cause of dietary health. Professor Dean Ornish says that, “everyone in the field of nutrition science stands on the shoulders of Dr. Campbell…this is the most important book about nutrition ever written. Whole Foods Founder John Mackey says, that The China Study is “the most important book on health, diet and nutrition ever written. Its impact will only grow over time and it will ultimately improve the health and longevity of tens of millions of people around the world.” Cornell President Frank Rhodes says that The China Study is “a lively, provocative book that deserves widespread attention.” Nobel Laureate Robert Richardson writes, “the relationship between diet and disease and his conclusions are startling [and] is a story that needs to be heard.” Junshi Chen, Chinese Academy of Sciences, says, that “The China Study is “the book of choice for … countries undergoing rapid economical transition and lifestyle change.” Hall of Fame Golfer Gary Player, on national TV, knelt down on camera and pleaded, “America, everyone needs to read this book!”

Dr. Campbell’s book, Whole, was written as a follow-up book to try to answer a commonly asked question. “Why hasn’t the public heard this information before?” Rather than focus on the many examples of corporate and political misbehavior, Dr. Campbell explored the scientific reasons why this message has been considered by some observers to be outside of normal science. In this effort, he offers a very different philosophy that not only explains the reasons for the rampant public and professional confusion about nutrition but also offers a new way to understand the enormous power of nutrition to maintain and restore health more effectively than any health protocol now in use. Much of this dialog and understanding arose from his studies on chemical carcinogenesis and, in doing so, he describes the significance of the research finding that the cancer process can be reversed by nutritional means. The book, now more than two years after being on the NY Times best seller list, still remains highly ranked and the publisher believes that it will have a very long life, thus the recent publication of a collector’s version.

Influential Publications & Presentations

Of the 350 research publications, the following are some of the more significant.

  • Campbell, T.C., Caedo, J.P., Jr., Bulatao-Jayme, J., Salamat, L. and Engel, R.W.  Aflatoxin M1 in human urine. Nature 227:403-404, 1970.
  • Campbell, T.C. and Stoloff, L.  Implications of mycotoxins for human health. J. Agr. Food Chem. 22:1006-1015, 1974.
  • Campbell, T.C. and Hayes, J.R.  Role of nutrition in the drug metabolizing enzyme system.  Pharm. Revs. 26:171-197, 1974.
  • Campbell, T.C.  Chemical Carcinogens and Human Risk Assessment.  Fed. Proc. 39:2467-2484, 1980.
  • Faris, R.A. and Campbell, T.C.  Permanently altered chemical carcinogen metabolism as related to the neonatal environment.  Science 211:719-721, 1981.
  • Appleton, B.S. and Campbell, T.C.  The effect of high and low dietary protein on the dosing and postdosing periods of aflatoxin B1 induced hepatic preneoplastic lesion development in the rat. Cancer Res. 43:2150-2154, 1983.
  • O’Connor, T.P., Roebuck, B.D., Peterson, F.J., Lokesh, B., Kinsella, J.E., Campbell, T.C.  Effect of dietary omega-3 and omega-6 fatty acids on development of azaserine-induced preneoplastic lesions in rat pancreas.  J. Natl. Cancer Inst.81:858-863, 1989.
  • Schulsinger, D. A., Root, M. M. & Campbell, T. C. Effect of dietary protein quality on development of aflatoxin B1-induced hepatic preneoplastic lesions. J. Natl. Cancer Inst. 81, 1241-1245 (1989).
  • Dunaif, G.E. and Campbell, T.C.  Relative contribution of dietary protein level and aflatoxin B1 dose in generation of presumptive preneoplastic foci in rat liver. J. Nutr. 78:365-369, 1987.
  • Chen, J., Campbell, T.C., Li, J., Peto, R.  Diet, lifestyle and mortality in China. A study of characteristics of 65 Chinese counties.  Joint publication of: Oxford University Press, Cornell University Press and The People’s Medical Publishing House, 1990, 896 pp.
  • Campbell, T.C., Chen, J., Liu, C., Li, J., Parpia, B.  Non-Association of aflatoxin with primary liver cancer in a cross-sectional ecologic survey in the People’s Republic of China, Cancer Research, 50:6882-6893,1990.
  • Brody, J. in New York Times C1, C14-15 (New York, 1990).
  • Youngman LD, Campbell TC.  Inhibition of aflatoxin B1-induced gamma glutamyl transpeptidase-positive (GGT+) hepatic preneoplastic foci and tumors by low protein diets:  evidence that altered GT+ foci indicate neoplastic potential. Carcinogenesis, 13:1607-1613, 1992.
  • Campbell, T.C., Chen, J., Brun, T., Parpia, B., Qu, Y., Chen, C., Geissler, C.  China: from diseases of poverty to diseases of affluence. Policy implications of the epidemiological transition.  Ecol. Food Nutr. 27:133-144, 1992.
  • Youngman, L. D. & Campbell, T. C. The sustained development of preneoplastic lesions depends on high protein diets. Nutrition and Cancer 18, 131-142 (1992).
  • Appleton, B. S. & Campbell, T. C. Dietary protein intervention during the post-dosing phase of aflatoxin B1-induced hepatic preneoplastic lesion development. J. Natl. Cancer Inst. 70, 547-549 (1983).
  • Hu, J., Cheng, Z., Chisari, F.V., Vu, T.H., Hoffman. A.R., Campbell, T.C. Repression of hepatitis B virus (HBV) transgene and HBV-induced liver injury by low protein diet. Oncogene 15:2795-2801, 1997.
  • Campbell, T.C. Untold Nutrition. Nutr. Cancer 66:1077-1082, 2014.
  • Campbell, T.C. The Past, Present, and Future of Nutrition and Cancer: Part 1- Was A Nutritional Association Acknowledged a Century Ago? Nutr. Cancer 69, 811-817, 2017.
  • Campbell, T.C. Nutritional Renaissance and Public Health Policy. J Nutr. Biol. 2017; 3(1): 124-138.
  • Campbell, T.C. Cancer Prevention and Treatment by Wholistic Nutrition. J. Nat. Sci. 3(10), e448.

The last two manuscripts are likely to be the most significant of Dr. Campbell’s career. They challenge widely used definitions of nutritional science and cancer etiology and treatment.

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